Septerna has a market cap of $750mn and $130mn in cash and ST investments. Discover SEPN's groundbreaking drug discovery ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

Recent advancements in understanding GPCR conformational changes and biased signaling have highlighted their critical roles in disease mechanisms. Age-related alterations in GPCR function, dynamics, ...

The most recent advances in the field have uncovered the pleiotropy and richness in GPCR signal transduction. A given GPCR might preferentially regulate a particular signaling pathway with specific ...

However, upstream signals that regulate the mammalian Hippo pathway have remained elusive. Here, we report that the Hippo pathway is regulated by G-protein-coupled receptor (GPCR) signaling.

An emerging principle in GPCR biology is that chemically distinct ligands that activate the same cognate receptor can produce different signaling responses. Ligand-selective signaling is motivating ...

We also develop phototropin and cryptochrome-based optogenetic tools for regulating G protein signaling independent of GPCRs. These engineered tools allow the acquisition of dynamic molecular pictures ...

Biasnet runs in two ways: Docker and manually running from source. With Docker, you can either pull an image from DockerHub, or build one on your own. The latest ...