Figure 1: Large-scale strategy for mutagenesis of the mouse genome: a conditional knockout vector is created for each gene and introduced into mouse embryonic stem (ES) cells. The mechanisms ...

A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

are collaborating with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides ...

Genetic changes are a significant cause of infertility, impacting over 15% of the global population. TLE6, a major protein ...

Researchers say study represents a resource that could also help to dissect Y-gene functions in other tissues.

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

Catherine Dulac, Harvard University Millership and Noordermeer both note that the study involved total knock out of the relevant alleles ... in this case focusing specifically on the activity of Ddc ...

Post-mortem examination of a mouse heart shows a clear delineation in blue where TREE gene enhancer sensed and responded to tissue damage of a heart attack. photo - Ken Poss Lab, Duke University ...

Researchers develop a novel Tle6 gene hetero knockout mice model to understand the role of this gene in male fertility and find that its deficiency results in abnormal sperm structure, reduced sperm ...

Like humans, mouse hearts cannot regenerate. For this study, “we looked at the activity of genes in damaged and healthy parts of the heart” in both mouse and zebrafish, Dennis de Bakker ...