It’s a new way to create “bi-paternal” mice that can survive to adulthood—but human applications are still a long way off.

A research group led by Wei Li at the Chinese Academy of Sciences has created mice born from two male parents and capable of ...

A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice.

Figure 1: Large-scale strategy for mutagenesis of the mouse genome: a conditional knockout vector is created for each gene and introduced into mouse embryonic stem (ES) cells. The mechanisms ...

are collaborating with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome. Knocking out the activity of a gene provides ...

Both gene knockout and knock-in models are powerful tools widely used in biomedical research to gain important insights into ...

New study reveals that TLE6 protein deficiency causes male infertility in mice. These findings suggest potential genetic ...

Catherine Dulac, Harvard University Millership and Noordermeer both note that the study involved total knock out of the relevant alleles ... in this case focusing specifically on the activity of Ddc ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...