CAR T-cell therapies have demonstrated efficacy in treating blood cancers but, so far, their safety and effectiveness in ...

A new study reveals that modifying the CUL5 gene enhances CAR-T cell therapy for leukemia and lymphoma. This improves cell ...

Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now ...

At this time, the flagship pipeline project is based on ACTengine, which takes a patient's T cells and genetically modifies them to express a proprietary T cell receptor, which is derived from T ...

A new advance may make it possible to use off-the-shelf CAR T cells provided by healthy donors. The new approach studied in mice equipped CAR T cells with the viral protein Nef.

Researchers have developed HuT mice, a genetically engineered model with human-like telomeres, enabling scientists to study ...

The study proposes engineering sentinel cells by genetically modifying autologous cells to record internal molecular and physiological signals directly into their genomes using DNA-based recording ...

A new approach that used CRISPR to engineer adipocytes and implant them in mice models of cancer reduced cancer progression.