Three of these six pathogens are antibiotic-resistant Gram-negative bacteria ... helix of class C β-lactamases with extended substrate spectrum.

Purpose: The pharmacology, spectrum of activity ... treatment of resistant gram-negative and gram-positive infections, especially in patients with a history of a penicillin allergy or ...

enteric and nonenteric gram-negative bacteria, including extended-spectrum β-lactamase-producing strains; and anaerobic pathogens. Doripenem was found to be noninferior to meropenem in the ...