The signaling pathways regulating differentiation into these two lineages are incompletely understood. The bulk of placental growth and development in the first trimester occurs under low oxygen ...

By using a dominant-negative mutant and small interfering RNA (siRNA) approaches, the lab has demonstrated that the association between HIF-1/2α and p300 is modulated by PKC z. Moreover, a novel ...

PT2977 is a small molecular inhibitor of HIF-2alpha, a key oncogenic driver within the VHL-HIF signaling pathway. Pre-clinical data indicates that this inhibitor blocks the association of HIF-2alpha ...