Coreceptors are responsible for a crucial step between Env binding to the receptor CD4 and membrane fusion mediated by the gp41 fusion peptide. Determinants of HIV cell tropism & chemokine ...

Viruses such as HIV-1 and poliovirus can enter and exit ... Figure 5: Conformational changes of viral fusion proteins leading to membrane fusion. A number of models have been suggested for fusion ...

Although it is known that molecules with anti-HIV activity circulate in human blood, their identification has been hampered by difficulties in the purification and characterization of such compounds.

"Since viruses cannot synthesize lipids, HIV 'steals' lipids from the plasma membrane of host cells," explains Toshihide Kobayashi of the RIKEN Pioneering Project on Integrated Lipidology.

2009;66(8):715-726. Mechanism of action of maraviroc. Before fusion of the HIV viral envelope and host cell membrane can occur, an HIV glycoprotein complex consisting of glycoproteins gp41 and ...

However, the HIV-1 envelope protein is highly ... that reveal key pieces of itself critical for viral fusion that were buried deep in the membrane. Consequently, the antibody is then able to ...