The Hedgehog (Hh) pathway plays central roles in animal development and stem-cell function. Defects in Hh signalling lead to birth defects and cancer in humans. The first and often genetically ...

Glypican members of the heparan sulphate proteoglycan family regulate several developmental signalling pathways, such as those involving Hedgehog, Wnt, BMP and FGF. Two studies reveal opposite ...

(Mukherjee et al. 2006) that showed increased mRNA expression in ~40 percent of their samples. Together, these data suggest altered hedgehog signaling occurs early, and often, in human breast disease ...

Objective Vascular remodelling during liver damage involves loss of healthy liver sinusoidal endothelial cell (LSEC) phenotype via capillarisation. Hedgehog (Hh) signalling regulates vascular ...

Itraconazole inhibited melanoma cell proliferation by inducing G1 phase arrest and autophagy-mediated apoptosis in A375 and A2058 cells. Furthermore, itraconazole suppressed Hedgehog signaling and ...

We aim to further elucidate the functional role of Notch signalling in OA using Notch1 antisense transgenic (Notch1 AS) mice. Methods Notch and hedgehog signalling were analysed by real-time PCR and ...

Effective antifibrotic treatments are not available. Here, the authors investigated inhibition of hedgehog signalling by targeting Smoothened (Smo) as a novel antifibrotic approach. Methods The ...

Several components of the hedgehog (Hh) pathway are crucial to ... The requirement for canonical Wnt/β-catenin signaling in Hh-driven BCC development is increasingly recognized.

Work in our lab is focused currently on understanding the role of the "Hedgehog" signal transduction network during normal mammary gland development, and whether altered hedgehog signaling may ...

Emerging evidence reveals that BD exhibits strong potency against colitis-associated colorectal cancer (CAC), with the underlying mechanisms elusive. Deregulated Hedgehog signaling pathway is ...

The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family ...