As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Histologic assessment of a liver biopsy specimen remains the gold standard for quantifying fibrosis, with increasing interest in the use of noninvasive markers to allow more frequent sampling and ...

The HepaStem cells have immunomodulatory properties, similar to other MSCs, and act on the hepatic stellate cells that ... and as such can carry markers that allow them to be identifiable as ...

Non-parenchymal cells like hepatic stellate cells (HSCs), Kupffer cells (KCs), and liver sinusoidal endothelial cells (LSECs) play a key role in fibrosis development. These cells are involved in ...