Interestingly, a substantial number of SLE patients produce IgE autoantibodies, suggesting that basophils may contribute to disease severity through their involvement in Th2-associated immunity[2].

to trigger basophil activation. The fact that in this context the BAT does not discriminate between IgE- and non-IgE-mediated reactions, should not be considered as a shortcoming. Finally ...

A recent study reveals the pivotal role of tristetraprolin (TTP), an RNA-binding protein, in regulating inflammatory responses in basophils, immune cells central to allergic reactions. The research ...

Basophils from each strain were stimulated with antigen combined with IgE, IL-33, or lipopolysaccharide (LPS). We measured gene expression, mRNA stability, and inflammatory protein levels.

Basophils from each strain were stimulated with antigen combined with IgE, IL-33, or lipopolysaccharide (LPS). We measured gene expression, mRNA stability, and inflammatory protein levels.

with anti-IgE or anti-IgE-receptor I, and fail to upregulate expression of CD63 and/or CD203c. Importantly, as activation of the basophil with N-formyl-methionine-leucine-phenylalanine (fMLP ...

Basophils from each strain were stimulated with antigen combined with IgE, IL-33, or lipopolysaccharide (LPS). We measured gene expression, mRNA stability, and inflammatory protein levels.