The innate immune system is characterized by a number ... changing the resulting protein signaling complexes that form and encouraging signalling through transcription factors such as C/EBPβ ...

The study of plant host-defense systems has also yielded great insight into the various components required for innate immune signaling. For example, analysis of NBS-LRR proteins has demonstrated ...

The common and important infectious viruses in pigs and poultry mainly include DNA and RNA viruses, which pose significant threats to both animal and human ...

In a pair of recent papers, scientists in the lab of molecular biologist John Petrini, Ph.D., showed that innate immune ...

In a pair of recent papers, scientists in the lab of molecular biologist John Petrini, PhD, showed that innate immune signaling plays a key role in maintaining genome stability during DNA replication.

The Alexander Gitlin Lab studies how inflammatory cell signaling controls the nature and magnitude of inflammation under physiological and disease conditions. Innate immune cells are tasked with ...

In vivo perturbations and single-cell RNA-seq reveal cell-type-specific STAT1-IFNg signaling in regulation of trained immunity in tissue-resident immune cells.

This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides ...

Areas covered include, but are not limited to, innate immunity and inflammation; development; immune receptors, signaling and apoptosis; antigen presentation; gene regulation and recombination ...

A research team at Memorial Sloan Kettering Cancer Center (MSK) has made new insights into how the body forms immune cell ...

We found that tumor-resident cytotoxic type 1 innate lymphoid cells (ILC1s ... cells with their CTL suppressor function titratable along the PI3K-Akt-Foxo1 signaling pathway to overcome cancer immune ...

Some of the cell's RNA molecules, researchers found, help regulate antiviral signaling. These signals are part of the intricate coordination of immune responses against virus invasion. A study in ...