Heterozygous or complete deletion of the insulin receptor in several tissues, including liver, skeletal muscle, neurons and pancreatic β-cells, leads to varying degrees of insulin resistance or ...

Both Inceptor and the insulin receptor are located on the surface of ... Inceptor binds to and directs insulin towards lysosomal degradation in β cells, Nature Metabolism (2024).

Type 1 diabetes is an autoimmune disorder in which the body's immune cells attack the β-cells ... and after insulin ...