Insulin receptor substrate (IRS)-1 is a multitask protein that interacts with many other proteins. IRS-1 is mitogenic, inhibits differentiation, protects from apoptosis and regulates cell (and ...

Attenuation of signalling through the insulin/insulin-like growth factor-1 (IGF1) pathways prolongs ... The regulation of ageing by some hormone-receptor pathways is cell non-autonomous; genetic ...