and the IGF-1 (insulin-like growth factor) receptor, which is essential for the survival of many tumor types. Signal transduction companies currently face two key challenges: First, the pathways ...

Signal transduction is a ... form of signaling where a soluble receptor interacts with a membrane-bound receptor to propagate a signal within the cell. MAPK Pathway: A signaling pathway that ...

Insulin and the ... were to affect leptin signal transduction as well, and the previous discussion highlighting cross talk between leptin and insulin signaling pathways emphasizes the feasibility ...

Cys-loop receptors are ligand-gated ion channels with two domains connected by a short linker. The top domain is located extracellularly, while the bottom domain sits in the cell membrane.

In 1982, he completed a postdoctoral fellowship at Brown University, where he worked on mechanisms of insulin action. Later that year ... Massagué identified the TGF-β receptors, their mechanism of ...