An oral insulin would both obviate the need ... These seem to act through binding to the extracellular ligand binding domain of the receptors, where they activate by inducing dimerization and ...

and mice with a fat-specific insulin-receptor deficiency are also long-lived. Lipophilic hormones, including steroids, also modulate ageing in worms and flies. Related lipophilic hormones are ...

The Discovery of New Members of the TNF Receptor and Ligand Families and Their Relationship to Osteoclasts and Bone Metabolism Binding of RANKL to RANK initiates a signaling cascade, which ...