The detailed sequence of events following ECM binding to the integrin is not known, but the β-subunit cytoplasmic domain interacts directly with talin, and talin interacts with both vinculin and ...

tKO fibroblasts in contact with collagen display severe defects in actin cytoskeleton organisation and integrin-based matrix adhesions, which result in strongly impaired force transduction and ...

Based on Xeljanz clinical trials ... including anti-TNF alpha agents, integrin receptor antagonists, interleukin inhibitors, ...