The detailed sequence of events following ECM binding to the integrin is not known, but the β-subunit cytoplasmic domain interacts directly with talin, and talin interacts with both vinculin and ...

These proteins, HER2 and α V β 6 integrin, are already known to independently predict cancer outcomes, but have now been found to work together through a newly discovered "crosstalk" mechanism ...

Rainero. The findings open new avenues for cancer treatment. One of the regulators identified, a molecule called a2b1 integrin, is of particular interest. By understanding how to block a2b1 ...

This transaction adds a pipeline of early-stage drug candidates against high-value targets including DLL3 and integrin avß6, as well as several other novel targets ... The acquired intellectual ...

A remarkable development in breast cancer research has revealed a fundamental mechanism behind driving cancer invasion and ...