The detailed sequence of events following ECM binding to the integrin is not known, but the β-subunit cytoplasmic domain interacts directly with talin, and talin interacts with both vinculin and ...

Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including milk thistle, turmeric, and green tea, that target the tumor ...

These proteins, HER2 and α V β 6 integrin, are already known to independently predict cancer outcomes, but have now been found to work together through a newly discovered "crosstalk" mechanism ...

Rainero. The findings open new avenues for cancer treatment. One of the regulators identified, a molecule called a2b1 integrin, is of particular interest. By understanding how to block a2b1 ...

The hypothalamic–pituitary–thyroid axis plays a crucial role in the pathogenesis, diagnosis, risk stratification, effectiveness of radioiodine therapy, and treatment response evaluation in epithelial ...

Researchers from the Medical Research Council/Cancer Research UK ... was the finding that this interaction required the β1 integrin subunit. The use of integrin subunit-blocking antibodies ...

The firm will pay $45 million upfront for several new targeted agents that it plans to pair with isotopes to develop both ...