Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including milk thistle, turmeric, and green tea, that target the tumor ...

The detailed sequence of events following ECM binding to the integrin is not known, but the β-subunit cytoplasmic domain interacts directly with talin, and talin interacts with both vinculin and ...

Fibrogenic cytokines and growth factors play an important role in this process; also the integrin-mediated interaction of fibroblasts with the surrounding extracellular matrix environment is a crucial ...

Specifically, molecules like integrin β1 (cells use this protein to attach to ECM) and α-catenin (cells use this protein to stick to one another) play crucial roles in this organization. Better ...

A substantial and persuasive body of data now exists that supports the view that integrin alpha V beta 3 plays a critical part in activated macrophage dependent inflammation, osteoclast development, ...

Experimental and mathematical models provide evidence that a change from high to low integrin activation state (high to low affinity for ligands) is required for cells to detach from their ECM ...

These are given by a Hamiltonian energy function. where Δ H FA is an additional penalty for breaking integrin bonds that the cell might have with the ECM at that location.