As Carbonell points out, “the requirement for integrin-mediated vascular co-option in brain metastasis establishment is very exciting from a therapeutic standpoint”. If future studies follow ...

Metastasis is responsible for most cancer-related ... One of the regulators identified, a molecule called a2b1 integrin, is of particular interest. By understanding how to block a2b1 integrin ...

Jim Norman and colleagues now report that RAB25 directly interacts with and localizes α5β1 integrin at the pseudopodial tips of migrating cells, thereby contributing to metastatic progression.