Importantly, tumor cells are able to switch their integrin expression and the type ... targeting of the various elements of the tumor microenvironment or targeting signaling pathways activated ...

Besides an extensive range of genetic and epigenetic alterations, components of the tumor microenvironment tend to exert a significant impact on tumor progression. The so-called tumor ...

A recent study uncovers how drug-resistant cancer cells induce changes in the tumor microenvironment. This phenomenon ...

Integrins are very attractive therapeutic targets in oncology. The anti-tumor mechanisms of integrin-targeting drugs have been validated both in vitroand in vivo. Integrin-targeting drugs are ...

An immuno-oncology targeting panel accurately characterized tumor-resident immune cells and located pathologically and clinically relevant tumor microenvironment features. Cancer development and ...

There is great need for therapeutics targeting both GI tumor-specific antigens and the immune system, and specifically to address the complexities of the solid tumor microenvironment (TME).

Poor response to chemotherapy and immunotherapy is due, in part, to the dense stroma and heterogeneous tumor microenvironment (TME). Opportunities to target the PDAC stroma may increase the ...