Without these genes, the mice exhibited defective signaling of a critical immune-modulating molecule called interferon-gamma, ...

The authors suggest that inhibition of IFN-γ signaling could provide a novel approach for the concomitant prevention of inflammation and bone loss in common osteoporotic conditions, including ...

IFI16 facilitates the inflammatory endothelial pathophenotypes observed among individuals with PAH, according to new research ...

Interferon gamma (IFN-γ) is a cytokine that induces ... These interleukins’ stimulatory effects also result from intracellular signaling of transcription factors such as AP-1, JAK/STAT, and ...

Regulatory T cells typically inhibit other immune cells, including those that produce interferon gamma. Knocking out calcium signaling in regulatory T cells unleashed the cells that produce ...

Moreover, we determined a significant upregulation of interferon-gamma signaling in infected BCECs. The latter was also detected in the neurovascular unit (NVU) in post mortem COVID-19 brain by ...

We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model of Mycobacterium avium infection (Nature 2010). Furthermore, ...

Regulatory T cells typically inhibit other immune cells, including those that produce interferon gamma. Knocking out calcium signaling in regulatory T cells unleashed the cells that produce ...