Our approach to organoid culture and differentiation involves the use of synthetic matrices to direct morphogenesis through tunable biochemical and mechanical signals. We spatiotemporally pattern ...

The authors examine the role of Numb, a Notch inhibitor, in intestinal stem cell self-renewal in Drosophila during homeostasis and regeneration. This is an important study providing evidence of a Numb ...

Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and ...

More information: Jaakko Mattila et al, Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation, Science Advances (2024). DOI: 10.1126/sciadv.adi2671 ...

An IBEC-led study describes the development of an innovative method to control the formation of crypt-like structures and ...

An IBEC-led study describes the development of an innovative method to control the formation of crypt-like structures and ...

A contact protein printing technique enables researchers to control the formation of villi in human gut models, making it ...

We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model of Mycobacterium avium infection (Nature 2010). Furthermore, ...

Food allergy, or the aggressive immune system reaction following the consumption of a certain food or food ingredient, typically involves immunoglobulin E (IgE) antibodies and can be potentially life- ...