Scientist Sarallah Rezazadeh from the Icahn School of Medicine explores the molecular mechanisms behind adult stem cells as ...

Our approach to organoid culture and differentiation involves the use of synthetic ... and bond formation to study how intestinal stem cell colonies respond to alterations in geometric confinement, ...

More information: Jaakko Mattila et al, Stem cell mTOR signaling directs region-specific cell fate decisions during intestinal nutrient adaptation, Science Advances (2024). DOI: 10.1126/sciadv.adi2671 ...

Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and ...

In addition to mechanistic studies, his lab developed novel organ culture methods to direct differentiation of human pluripotent stem cells into intestinal tissue to study intestinal development and ...

An IBEC-led study describes the development of an innovative method to control the formation of crypt-like structures and ...

A contact protein printing technique enables researchers to control the formation of villi in human gut models, making it ...

The authors examine the role of Numb, a Notch inhibitor, in intestinal stem cell self-renewal in Drosophila during homeostasis and regeneration. This is an important study providing evidence of a Numb ...