Hereditary hemochromatosis is an inherited iron overload disorder caused by inappropriately low hepcidin secretion leading to increased duodenal absorption of dietary iron, most commonly in C282Y ...
Iron-overload diseases result from inappropriate iron acquisition in response to iron need. Excess iron can damage tissue, cause fibrosis and give rise to organ failure. Iron-deficiency disorders ...
Today, we will focus on the dangers of blood exchange or transfusion and the risk of iron overload. In conditions like Sickle Cell Disease, regular blood transfusions or exchanges are used to ...
This iron overload triggered ferroptosis and tissue damage. Critically, when they treated the mice with drugs that inhibit ferroptosis or mop up iron, I/R injury was less severe 4. The same set of ...
I agree with Wolf’s concerns about transfusion in sickle cell disease.12 In developed countries, where the blood donor pool is predominantly white and lacking the Ro antigen, transfusion for sickle ...
Doctors estimate as many as one in three adults may have undiagnosed iron deficiency. Iron is a key nutrient that helps red blood cells carry oxygen throughout the body. “So, if we’re low in it, we’re ...