Itaconate is a metabolite derived from the Krebs cycle, primarily produced in activated macrophages. Recent research has highlighted its significant role in modulating inflammation and immune ...

Itaconate is produced by macrophages in the tumor microenvironment, which means there exists a detrimental crosstalk between ...

Itaconate is an anti-inflammatory substance that the body naturally produces inside its mitochondria. Macrophages produce it early on when they are activated so that the inflammatory reaction will ...