antibodies (nanobodies) that target the transferrin receptor, which is responsible for the transport of iron into the brain, as another type of vector to deliver drugs to the CNS. Both LDL and ...

Familial hypercholesterolemia results from gene mutations approximately halving the number of functional LDL receptors in heterozygotes and a greater lack in homozygotes. Reduced receptor-mediated ...

In contrast, eNOS is not activated by purified forms of the major HDL apolipoproteins ApoA-I and ApoA-II or by low-density lipoprotein ... reveal that scavenger receptor-BI (SR-BI) mediates ...

If they’re not absorbed, LDL particles can accumulate to harmful ... drugs already” that it may be challenging for new antibody-based therapies to compete.