In humans, many leptin deficiency syndromes are responsive to ... who have normal genes for leptin and its receptor, are leptin resistant. Despite extensive efforts in many laboratories, it ...

In turn, that weight gain and excess fat cells can contribute to leptin resistance. Leptin receptor deficiency is a rare genetic condition causing a person to be born with few leptin receptors.

is a purported satiety factor with receptors in the hypothalamus. Human leptin is a relatively small protein (16 kDa) which shares a high degree of homology with other species such as mice (84%) and ...

deficiency or leptin receptor deficiency. BBS and POMC, PCSK1 and LEPR deficiencies are rare melanocortin-4 receptor pathway diseases with hallmark characteristics that include hyperphagia ...

"The findings support the known role of leptin variations in late-life dementia risk by relating its deficiency with changes ... its soluble leptin receptor and their ratio, known as the free ...