As things turned out, however, the Laboratory provided a very fertile environment—with excellent colleagues and world-class mouse models ... In humans, many leptin deficiency syndromes are ...

Abstract and Introduction Research Design and Methods Results Discussion References Finally, accelerated diabetes occurred in leptin-treated female mice only when leptin administration was started ...

Mice with a disruption of leptin signaling showed a 3-fold increase ... it appears they have a resistance to the effects of the hormone where the body does not receive the signal it is full ...

Human leptin is a relatively small protein (16 kDa) which shares a high degree of homology with other species such as mice (84%) and rats (83%). Although rare in humans, leptin mutations in mice ...

Our project goal is to quantify how leptin signaling alters adaptive orienting to visual cues with distinct valence. Parallelly, we are also investigating sexual dimorphism in visually guided approach ...

Daniel T. Eitzman, a cardiologist and assistant professor of internal medicine, studied varying leptin levels in mice. Eitzman looked at a group of overweight mice that were genetically engineered ...

The GLP-1 analog also improved leptin resistance, “a major biological contribution to obesity.” SAN ANTONIO — Utreglutide, a novel GLP-1 analog, when administered in multiple ascending doses ...