In humans, many leptin deficiency syndromes are responsive to leptin replacement therapy. As leptin is involved in numerous pathways, the effects of too little leptin are widespread (including ...

However, there may be circumstances where a person develops a resistance to leptin, weakening the body’s reactivity to the hormone. This unfavourable circumstance could result in overeating ...

The GLP-1 analog also improved leptin resistance, “a major biological contribution to obesity.” SAN ANTONIO — Utreglutide, a novel GLP-1 analog, when administered in multiple ascending doses ...