ER stress and the saturable nature of leptin signaling pathways play a key role in the development of leptin tolerance in obese patients with diabetes. In the context of a large, randomized ...

The Nmu gene was targeted for deletion by standard techniques (Supplementary Fig. 1 online). Nmu-/-mice were generated on a BL6/129 mixed background and backcrossed four times into C57BL/6J mice.

Their subjects all lost 10% weight and hence it is necessary to understand the Leptin hormone pathway. When Leptin injections are given to people who have normal body weight there is no reaction ...