C. 5.3.1.9) (glucosephosphate isomerase, or GPI) that was evident in proband leukocytes as well as erythrocytes. 2,3 Further studies of three similar cases in an unrelated family constitute the ...

1a). This mechanism has evolved to maintain a pool of HSCs sufficient for a normal lifespan while generating, on a daily basis, billions of mature leukocytes, erythrocytes and platelets.

This paper demonstrates a previously undescribed defect of a glycolytic enzyme, triosephosphate isomerase, in the erythrocytes and leukocytes of a patient with congenital hemolytic anemia.