especially as the ligand-binding pocket and ligand-receptor interactions for β2AR show some substantial differences with rhodopsin. However, as mentioned earlier, the exact conformation that the ...

Interactions at a ligand binding level had been proposed and were strengthened by mounting pharmacological evidence. Binding assays were critical in assessing the hypothesis that opioid receptors ...

The Discovery of New Members of the TNF Receptor and Ligand Families and Their Relationship to Osteoclasts and Bone Metabolism Binding of RANKL to RANK initiates a signaling cascade, which ...

G protein-coupled receptors (GPCRs), crucial for diverse physiological responses, have traditionally been investigated in ...

By understanding how lipid interactions regulate DP2 activity ... Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2, Proceedings of the National Academy of Sciences ...

"The elucidation of key residues causing selectivity not only enhances the understanding of ligand-receptor interactions within the NPFF receptor system but also paves the way for rational drug ...

Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian ... and advances in understanding ...

With specialized expertise in GPCRs (G protein-coupled receptors) and other membrane proteins ... Through iterative computational optimization, we refine ligand specificity and activity, fine-tuning ...