Chronic inflammation, particularly when it occurs in metabolically important organs such as the liver and adipose tissue, has a crucial role in the emergence of many chronic metabolic diseases ...
The liver and pancreas are the main actors in glucose metabolism, but not the only ones. Muscles, adipose tissue and the brain play different roles. However, the prize for the best new actor in ...
When metabolic endotoxemia was induced for 4 weeks in mice through continuous subcutaneous infusion of LPS, fasted glycemia and insulinemia and whole-body, liver, and adipose tissue weight gain ...
brown adipose tissue (BAT) burns it, generating heat. As people age, BAT diminishes, increasing obesity risk. SerpinA1, a hepatokine secreted by the liver, has been shown to reverse this process ...
Our recent work suggested that BA overload in mice genetically deficient for the nuclear receptor FXR and SHP (double knockout, DKO) results in unexpected beneficial anti-obesity and anti-diabetes ...