Structural variants (SVs) reach up to the megabase scale and account for 10 times as many variants as single nucleotide polymorphisms in the human genome. They contribute to a range of normal and ...

No single method will provide the means to detect the total complement of genomic structural variation. Even the highest-resolution analysis — genome re-sequencing — would resolve only a ...

But UC Santa Cruz researchers are pushing forward research on a cutting-edge alternative method, called long-read sequencing, which can provide a more comprehensive dataset for finding variation ...

Now, a group of researchers present data that suggests that long-read sequencing may be the better road to go down for these people. The more comprehensive dataset can find variation, eliminate ...

But UC Santa Cruz researchers are pushing forward research on a cutting-edge alternative method, called long-read sequencing, which can provide a more comprehensive dataset for finding variation ...

This will deepen the scientific community’s collective understanding of genomic features like tandem repeats, structural variants and methylation ... and has played a role in the development of ...

Using genome sequencing ... of these structural variations on cell survival. The research shows that as long as essential genes remain intact, our genomes can tolerate significant structural changes, ...

Using genome sequencing ... genomes are extremely tolerant of structural variation, including variants that change the position of hundreds of genes, as long as essential genes are not deleted4.