losartan (100 mg/day); and losartan (100 mg/day) plus hydrochlorothiazide (25 mg/day). Proteinuria was reduced by 22% from baseline with the low-sodium diet alone and by 30% with losartan alone.

Patients with severe hypertension are at high risk for cardiovascular events. The authors hypothesized that initial treatment with a combination angiotensin receptor blocker/diuretic agent would ...