Gonadotropin hormone receptors, specifically the follicle-stimulating hormone receptor (FSHR) and luteinizing hormone receptor (LHCGR), play a crucial role in regulating reproductive functions.

The regulator approved the indication based on data showing Kisqali with an aromatase inhibitor improved invasive disease-free survival versus just an aromatase inhibitor.

In particular, just before ovulation, when the hormones 17β-estradiol and luteinizing hormone rise ... pituitary-gonadal-axis ...

They decrease the secretion of hypophysial-luteinizing hormone and follicle-stimulating ... effect by their linkage with the androgenic receptor. On the other hand, progestins counter the ...