To pinpoint the individual components of the missing pathway, Tan used a lentivirus to express an enzyme called Turbo-ID in human cells, which sticks a biotin tag onto any protein within a ...

This creates a message: the lysosome and the cell are stressed ... to everyone by improving our knowledge of the complexities ...

On screening human cells to identify proteins that shuttled from the cytosol to the nucleus during STING activation, they identified 17 candidates. Among these, the transcription factors EB (TFEB) and ...

Lysosomes are organelles found within nearly all eukaryotic cells and are responsible for ... a gene most often found in human cardiac or skeletal muscle tissue, responsible for regulating ...

SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in microglia.