Nature3y
GPCRs are membrane-bound proteins that have seven membrane-spanning domains connected by intracellular and extracellular domains.
In the active form, the G-alpha-subunit bound to GTP and the beta-gamma complex can signal to downstream effector molecules (c). G-protein coupled receptors regulate hormone secretions in the ...
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Hormone receptor structure reveals how it functions in heart disease
Weill Cornell Medicine researchers have determined the full-length structure of a blood pressure-regulating hormone ... transmembrane receptor protein that spans the cell membrane, connecting ...
Nature4y
G-Protein-Coupled Receptors, Pancreatic Islets, and Diabetes
G-protein coupled receptors regulate hormone secretions in the pancreas ... the largest of which is the GPCR family. GPCRs are membrane-bound proteins that have seven membrane-spanning domains ...