For example, in Xenopus, mesoderm tissue undergoing convergent extension consists of a bilayer of cells sandwiched between two layers of the extracellular matrix component fibronectin, allowing ...

Embryonic stem cells (ESCs) can be propagated indefinitely ... We characterize a population of early mesoderm-specified (EM) progenitors that is generated from mouse ESCs by bone morphogenetic ...

During embryonic stem cell (ESC) development, pluripotent stem cells transition ... they captured an image eight days after culture that included the epiblast, yolk sac, extra-embryonic mesoderm, and ...

We work in two areas. The first is traditional cell and molecular biology, focussed on the molecular mechanisms underlying mesoderm formation, and neural crest induction, and tissue and organ ...

Further cell divisions lead to the formation of the primitive endoderm ... into the three germ layers that will construct all other bodily tissues: ectoderm, mesoderm, and endoderm. “This opens a ...

Pluripotent stem cells have the potential to differentiate into any of the three primary tissue types—endoderm (such as the ...