Embryonic stem cells (ESCs) can be propagated indefinitely ... We characterize a population of early mesoderm-specified (EM) progenitors that is generated from mouse ESCs by bone morphogenetic ...

For example, in Xenopus, mesoderm tissue undergoing convergent extension consists of a bilayer of cells sandwiched between two layers of the extracellular matrix component fibronectin, allowing ...

We work in two areas. The first is traditional cell and molecular biology, focussed on the molecular mechanisms underlying mesoderm formation, and neural crest induction, and tissue and organ ...

During embryonic stem cell (ESC) development, pluripotent stem cells transition from a naïve state ... they captured an image eight days after culture that included the epiblast, yolk sac, ...

Pluripotent stem cells have the potential to differentiate into any of the three primary tissue types—endoderm (such as the ...