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Researchers discover a promising compound to treat neuropathic pain
We and others have shown that σ2R/TMEM97 ligands alleviate mechanical hypersensitivity in mouse neuropathic pain models with a time course wherein maximal antinociceptive effect is approximately ...
Morphine tolerance found to result from Tiam1-mediated maladaptive plasticity in spinal neurons
Using a mouse model of neuropathic pain, Li and Tolias reported last year in the journal Neuron that Tiam1 acts to coordinate ...