Blocking this pathway in mouse brains modeled on Alzheimer's prevented damage to their synapse connections and ... causes brain immune cells called microglia to go 'dark' and start damaging ...

Toxic Lipid Secretion: The ISR pathway in microglia was shown to drive the synthesis and release of harmful lipids that contribute to synapse loss, a hallmark of Alzheimer's disease. Therapeutic ...

Microglia’s stress response drives toxic lipid production linked to Alzheimer’s progression. Blocking stress or lipid pathways reversed synapse loss in preclinical Alzheimer’s models. Findings ...

During development, there are known sex-related differences in how microglia function. But into adulthood, there was thought to be less variation in how they behave. Microglia maintain neuronal ...

Other variants shift AD risk in East Asians and Europeans. SORL1 dysfunction messes with endosomes in neurons, and with lysosomes in microglia. Where does the field stand now, 18 months later? On the ...

Specifically, the toll-like receptor 4 appears to be a site at which drugs of abuse activate microglia. Toll-like receptor 4 activation ... demonstrates that the tripartite and tetrapartite synapse ...

Changes in synapse number, proteins involved in synaptogenesis, and axon outgrowth may lead to imbalances in excitation and inhibition, and improper connectivity between specific brain regions. Recent ...