In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be ...

A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...

Here, the researchers review the involvement of mitochondrial and autophagy dysfunction in neurodegenerative disorders specifically focusing on Alzheimer's, Parkinson's and Huntington's disease ...

Autophagy, the process by which cells recycle damaged components, has long been associated with neuroprotection. However, the ...

The transferred mitochondria trigger the cell to destroy its low-performing mitochondria through autophagy—a kind of cellular ...

We are driven to understand the signals regulating tissue-specific autophagy signalling in mammalian health and disease. Understanding the physiological regulation and significance of selective ...

Autophagy, the cell's essential housekeeping process, involves degrading and recycling damaged organelles, proteins, and other components to prevent clutter. This vital mechanism, found in all ...

Mitophagy is a selective form of autophagy via which the damaged mitochondria are cleared via the autophagy-lysosome pathway. Mitophagy is an essential part of mitochondrial quality control and ...

Mitophagy is a selective form of autophagy via which the damaged mitochondria are cleared via the autophagy-lysosome pathway. Mitophagy is an essential part of mitochondrial quality control and ...

Transient Ca 2+ fluctuations on the surface of the endoplasmic reticulum (ER) can induce liquid-liquid phase separation (LLPS) of the autophagy initiation complex FIP200, forming FIP200 puncta and ...