Here, the researchers review the involvement of mitochondrial and autophagy dysfunction in neurodegenerative disorders specifically focusing on Alzheimer's, Parkinson's and Huntington's disease ...

Autophagy: A Process of Self-Digestion For ... They observed that the outer membrane of the mitochondria was the main membrane source, with some contribution from the endoplasmic reticulum ...

"Our research demonstrates that autophagy isn't just about clearing damaged mitochondria or protein aggregates," explained first author Dr. Janine Tutas. "In Purkinje cells, ATG5 actively ...

The transferred mitochondria trigger the cell to destroy its low-performing mitochondria through autophagy—a kind of cellular ...

A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...

This process, known as autophagy, is like a self-cleaning mechanism for cells, ... Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no ...

We are driven to understand the signals regulating tissue-specific autophagy signalling in mammalian health and disease. Understanding the physiological regulation and significance of selective ...

Dr. Weickert will present Pacylex at the OBIO® Investment Summit and Early Technology Showcase February 5-7, 2025, at the Arcadian Court & Loft, Toronto Mr. Kamdar will present Pacylex at the PWMC ...

Transient Ca 2+ fluctuations on the surface of the endoplasmic reticulum (ER) can induce liquid-liquid phase separation (LLPS) of the autophagy initiation complex FIP200, forming FIP200 puncta and ...

Hitherto his scientific breakthroughs regard the characterisation of pathways governing homeostasis of mitochondria and their quality control regulation via targeted autophagy (mitophagy). His ...

Autophagy loss increases PC vulnerability, independent of its role in protein and mitochondria quality control. Credit: Nature Metabolism (2025). DOI: 10.1038/s42255-024-01196-4 ...