proposing that mitochondria are the source of the free radicals. As Harman’s free-radical theory of aging took hold, it fueled research into cancer, Alzheimer’s and many other diseases.

Mitochondria are central to energy production in cells, and their dysfunction is increasingly implicated in the aging process and the pathogenesis of ...

(Mitochondrial DNA, in contrast ... Key Concepts in the Genetic Theory of Aging The key concepts in genetics and aging include several important concepts and ideas ranging from telomere shortening ...

Ziegler and his team also discovered that if mitochondria does not have enough NAD stored up, it can have a fatal consequence for the cell. “Our study connects two hallmarks of aging ...

Vijg describes this genome and discusses the significance of DNA damage to mitochondria, which may be an important signaling factor in the aging process. A leading theory of aging, which he ...

In summary, the researchers found that PAGln, a gut microbiota-derived metabolite, significantly contributes to cellular senescence and aging through mitochondrial dysfunction and DNA damage.

Researchers observed the largest lifespan extension when they targeted the catalase to mitochondria, which are thought to ... The results lend support to the free-radical theory of aging, which ...