CIII allows people who have tried at least two oral antidepressants to use the spray on its own – without the need for more ...

Initially 2 sprays in each nostril once daily or 1 spray in each nostril twice daily ... Monitor for candida infection or other nasal mucosal changes. Avoid eyes. Pregnancy.

People with treatment-resistant depression can now take Spravato's ketamine-derived nasal spray as a standalone treatment.