The primary goal of mouse mutagenesis programmes is to develop a fundamental research infrastructure for mammalian functional genomics and to produce human disease models. Many large-scale ...

We suggest that attributing phenotypes to genetic background effects is outmoded and that new databases containing single-nucleotide polymorphisms obtained with a group of inbred mouse strains can ...

Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact ...

A study conducted by a research team at the Crick Institute identified important genes on the Y chromosome that regulate sperm development and male fertility. Using thirteen mouse models, the ...

张召实验室位于德克萨斯大学西南医学中心（UT Southwestern Medical Center）的宿主防御遗传学中心（Center for the Genetics of Host Defense）。该中心由诺贝尔奖得主Bruce ...

Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact ...

Researchers say study represents a resource that could also help to dissect Y-gene functions in other tissues.

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends ...

A little-known mouse protein disrupts cancer-causing chemical changes to genes associated with human colorectal cancer cells and potentially could be used to treat solid tumors, according to a new ...

Deficiencies in the SLC6A1 gene, encoding the γ-aminobutyric acid transporter GAT-1, are associated with infantile encephalopathy with intellectual disability. Like other neurodevelopmental disorders, ...

Depression is a highly prevalent disorder, and researchers still have a lot to learn about its biological underpinnings.