When the molecule was removed in a preclinical mouse model, several negative effects were observed, including adipose tissue insulin resistance, hyperglycemia, hyperinsulinemia, and hyperlipidemia.

Figure 1: The signalling pathway by which insulin inhibits GSK3 and contributes to the stimulation of glycogen and protein synthesis. Figure 4: The molecular mechanism by which phosphorylation ...

Using fluorescence microscopy, they tracked the glowing molecule all the way to the brain ... Abhilasha noted that they are already designing experiments using cocultured mouse intestinal and ...

The team validated this finding in mouse models as well as in experiments using insulin-secreting cells donated from humans. The findings suggest that lower levels of circulating very long chain ...

Our laboratory is focused on the function of miRNAs in control of insulin production and secretion in pancreatic beta cells. We have successfully developed a high-throughput miRNA array technology for ...