The combination of topotecan and cisplatin resulted in improved efficacy in two of the four mouse xenografts. However, the cisplatin and topotecan combination was lethal in all treated mice.

Moreover, mouse macrophages can eliminate human xenografts , but phagocytosis is supressed by interactions between CD47 and SIRPα. Interestingly, the NOD allele encoding SIRPα has a high ...